Monday, November 24, 2008

The experimental proof of proteome splice variants


It turns out that still there are some common intuitions that has not been proven experimentally. The paper by Tress et al in Genome Biology shows that there are splicing variants on the level of proteome - namely the bits of a proteine may be deleted, shuffled or duplicated according to the patern of exons in the gene. For me it seemed to be obvious, but perhaps I am too deep in my world of genes and mRNA splice variants. Some may call it a low hanging fruit - but often is not that obvious to pick it...

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