The experimental proof of proteome splice variants

It turns out that still there are some common intuitions that has not been proven experimentally. The paper by Tress et al in Genome Biology shows that there are splicing variants on the level of proteome - namely the bits of a proteine may be deleted, shuffled or duplicated according to the patern of exons in the gene. For me it seemed to be obvious, but perhaps I am too deep in my world of genes and mRNA splice variants. Some may call it a low hanging fruit - but often is not that obvious to pick it...

Linkage disequlibrium leads to negative results in genetics?

Linkage disequilibrium is a method used to discover associations between alleles. It seems to be based upon simple difference between the probability of a combination alleles and the probability under independence assumption. So - some researchers took their favourite alleles, found associated ones and... got nothing. But it seems to be still enough to publish:

We did not find the deletion or any
of the STR alleles to be in linkage disequilibrium with the 2-marker haplotype,
which was associated with dyslexia in our sample.

The polymorphisms of GRIN2B gene analysed in this study are not likely to be associated with bipolar disorder.

Both negative, both in psychiatry journal. Perhaps a coincidence... Next month
I'll go to a neuroscience-related event (the last speaker's name looks strangely familiar...) maybe I'll learn more.

Still, there is a Journal of Negative Results in BioMedicine . It even navigates towards having an impact factor. I need to redirect some of my users there :)